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Particularly, as in DIM-5, these two enzymes depend on residues carboxy-terminal to the SET domain for the formation of lysine channel, but they do so by packing of an α helix, somewhat than a metal middle, onto the energetic site. Collectively, the crystallographic studies of SET7/9 and DIM-5 sure to histone H3 peptides have supplied a framework for understanding the histone lysine specificity of different SET-domain enzymes.
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